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A cortisol supplement built around KSM-66 Ashwagandha at 600mg, with ten more botanicals and Vitamin B6. Formulated for the stress, sleep and energy dips that come with a full life, and for the cycle changes underneath them.
KSM-66® Ashwagandha at 600mg, the dose most commonly used in clinical research, with Rhodiola and Chamomile. All three are traditionally used as adaptogens, a class of botanicals used to help the body adapt to everyday stress. Vitamin B6 contributes to normal psychological function.
Chamomile is traditionally used to support relaxation and restful sleep, paired with Ashwagandha. If you are the kind of tired that cannot switch off, this is the part of the formula aimed at you.
Vitamin B6 contributes to normal energy-yielding metabolism and the reduction of tiredness and fatigue. Maca and Rhodiola are traditionally used to support vitality during demanding periods.
Vitamin B6 contributes to normal psychological function and the regulation of hormonal activity.
Chaste Tree (Vitex) has been traditionally used to support a regular monthly cycle and premenstrual comfort.
Vitamin B6 contributes to the regulation of hormonal activity, with Wild Yam and Maca traditionally used in women's herbal support around the perimenopausal transition.
Vitamin B6 health claims are authorised on the GB Nutrition & Health Claims Register. Botanical claims are based on traditional use and are not authorised health claims. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
Cortisol is the body's main stress hormone. It follows a daily rhythm, highest in the morning and lowest late at night, and it is supposed to rise and fall. Most people searching for a cortisol supplement are not looking for a medical intervention. They are tired, wound up, sleeping badly, and looking for something to take alongside the sleep and the walks and the trying to work less.
The category is mostly adaptogens. Ashwagandha, Rhodiola, Holy Basil, sometimes Magnolia or L-theanine, usually with magnesium or B vitamins. Adaptogens are a class of botanicals traditionally used to help the body adapt to everyday stress. They have a long history of traditional use and a growing but not settled evidence base.
Four things worth checking before you buy any cortisol supplement.
The one that matters most. Look for a standardised extract at a dose used in research, not raw root powder at an unstated strength.
Ours: KSM-66® at 600mg, the branded full-spectrum extract that most clinical studies have used.
A standardised extract guarantees a consistent level of active compounds in every batch. Raw powdered herbs vary enormously between harvests.
Ours: every botanical is a standardised extract, from 8:1 to 20:1.
Many formulas lean on one ingredient and pad the rest. Check the dose beside every name, not just the ingredient list.
Ours: all 11 doses published in full, just below.
This is the tell. There is no authorised health claim in the UK for reducing, lowering or blocking cortisol, so any brand promising that is making a claim it cannot support.
Ours: we are not going to make it either.
11 botanicals plus Vitamin B6, in a 3-capsule daily dose. Tap any ingredient to see the detailed breakdown, traditional use, and safety information.
| Ingredient | Dose per 3 capsules |
Traditional or authorised use | |
|---|---|---|---|
| KSM-66® Ashwagandha Withania somnifera root extract | 600 mg | Traditionally used as an Ayurvedic adaptogen to support the body's response to everyday stress. | |
| Fennel Seed Extract 10:1 Foeniculum vulgare | 500 mg | Traditionally used to support digestive comfort and a healthy menstrual cycle. | |
| Maca Root Extract 10:1 Lepidium meyenii | 350 mg | Traditionally used in the Andes to support vitality and energy during demanding life stages. | |
| Chamomile Flower Extract 10:1 Matricaria chamomilla | 220 mg | Traditionally used to support relaxation and restful sleep. | |
| Rhodiola Rosea Root Extract 10:1 Rhodiola rosea | 80 mg | Traditionally used as an adaptogen to support mental and physical resilience under stress. | |
| Chaste Tree Extract 10:1 Vitex agnus-castus | 75 mg | Traditionally used to support hormonal balance and a regular monthly cycle. | |
| Wild Yam Root Extract 8:1 Dioscorea villosa | 60 mg | Traditionally used in women's herbal support around perimenopause. | |
| Broccoli Sprout Extract 20:1 Brassica oleracea | 50 mg | Source of sulforaphane, traditionally used to support the body's natural detoxification pathways. | |
| Gymnema Sylvestre Leaf Extract Gymnema sylvestre | 50 mg | Traditionally used in Ayurveda to support healthy sugar handling and curb sweet cravings. | |
| Rosemary Leaf Extract 8:1 Salvia rosmarinus | 25 mg | Traditionally used as an antioxidant-rich culinary and medicinal herb. | |
| Vitamin B6 EFSA approved Pyridoxine HCl | 2.07 mg 148% NRV |
Contributes to the regulation of hormonal activity, normal energy-yielding metabolism, normal psychological function, the reduction of tiredness and fatigue, and the normal function of the immune system. |
Capsule shell: hydroxypropylmethylcellulose (HPMC).
Vitamin B6 health claims are authorised on the GB Nutrition & Health Claims Register. Botanical claims are based on traditional use and are not authorised health claims under Regulation (EC) No 1924/2006. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
Withania somnifera root extract
Traditional useKSM-66 is the most clinically researched, full-spectrum, standardised root extract of ashwagandha on the market. Around 15 health-claim dossiers covering stress, mental performance and vitality sit on the EFSA Article 13.1 "on-hold" botanical list — a transitional regime under EU Regulation 1924/2006.
Ashwagandha is traditionally used in Ayurveda as an adaptogen — a class of plants used to help the body adapt to everyday stress. We use a 600 mg daily dose because that's the level most commonly studied in clinical trials.
If you take medication for an underactive thyroid (such as levothyroxine), or have a thyroid condition, speak to your GP before starting. Ashwagandha has been shown in clinical studies to influence thyroid hormone levels. The UK Food Standards Agency has issued a Call for Evidence on ashwagandha following Denmark's 2023 ban.
Foeniculum vulgare
Traditional useFennel has been used for thousands of years across Mediterranean and Middle Eastern herbal traditions to support digestive comfort and a healthy menstrual cycle. We use a 10:1 standardised extract, so the 500 mg dose delivers the equivalent of 5 g of dried fennel seed.
It's a long-standing women's-health botanical, included here for its traditional use in cycle-related digestive comfort and bloating.
Lepidium meyenii
Traditional useMaca is a Peruvian Andean root traditionally used to support energy, stamina and vitality during demanding life stages. It's non-hormonal — it doesn't contain phytoestrogens — which makes it a popular choice in stacks designed to be taken alongside (not instead of) HRT.
The 350 mg of 10:1 extract is equivalent to 3.5 g of dried maca root, in line with traditional usage ranges.
Matricaria chamomilla
Traditional useChamomile is one of the most widely used calming botanicals in Western herbalism, traditionally used to support relaxation and restful sleep. It's been part of European medicinal practice for over two thousand years.
Pairs well with Ashwagandha in our evening-leaning calm profile.
Rhodiola rosea
Traditional useRhodiola is a Scandinavian and Russian adaptogen traditionally used to support mental and physical resilience under stress. Where Ashwagandha tends to feel calming, Rhodiola tends to feel "energising" — together they cover both demand profiles across the day.
Vitex agnus-castus
Traditional useChaste Tree (also known as Vitex or Agnus Castus) is the most-researched herb in Western herbal medicine for premenstrual comfort and cycle regularity, traditionally used to support a healthy monthly cycle.
The 75 mg of 10:1 extract is equivalent to ~750 mg of dried fruit, in line with the 20–80 mg of extract used in clinical research.
Chaste Tree is not suitable if you are using hormonal contraception (combined pill, progestogen-only mini pill, hormonal IUS, or implant). The Australian Therapeutic Goods Administration safety alert (2019) reported two case reports of unintended pregnancy in women using Vitex concurrently with hormonal contraception.
Use additional non-hormonal contraception, or pause Hormonal Balance, if you're using hormonal contraception. Speak to your GP if in doubt.
Dioscorea villosa
Traditional useWild Yam is a traditional women's herbal support, used in Western herbalism around the perimenopausal transition. It contains diosgenin, a plant compound historically used as a starting material for synthetic steroid manufacture in laboratories — but the human body does not convert dietary diosgenin into progesterone. We include it for its traditional role, not as a "natural progesterone".
Per Memorial Sloan Kettering Cancer Center, avoid Wild Yam if you have, or are at increased risk of, a hormone-sensitive condition such as breast, ovarian or uterine cancer, endometriosis, or uterine fibroids. Also avoid if you have protein S deficiency. Speak to your GP or specialist if in doubt.
Brassica oleracea
Traditional useBroccoli sprouts are the most concentrated dietary source of glucoraphanin, the precursor to sulforaphane — a compound studied for its support of the body's Phase II detoxification enzymes via the Keap1/Nrf2 pathway.
Often used in women's-health stacks alongside cruciferous vegetables for liver detoxification support.
Gymnema sylvestre
Traditional useGymnema is an Ayurvedic herb traditionally used to support healthy sugar handling and to reduce the perception of sweetness on the tongue — its Sanskrit name "gurmar" literally means "sugar destroyer".
Useful for the blood-sugar swings that drive premenstrual sugar cravings.
Salvia rosmarinus
Traditional useRosemary is a polyphenol-rich culinary and medicinal herb traditionally used as an antioxidant and circulatory tonic. The 25 mg dose of 8:1 extract is equivalent to 200 mg of dried rosemary leaf.
Pyridoxine HCl
EFSA approvedThe compliance and clinical workhorse of the formula. Vitamin B6 has five authorised EFSA health claims on the GB Nutrition & Health Claims Register that map directly to the symptoms women are searching for:
B6 is well below the UK Vitamins & Minerals Guidance level of 10 mg/day and well below the EFSA tolerable upper limit of 25 mg/day.
Three capsules a day, covering the four things a cortisol supplement for women actually needs to address. Every claim below is either an authorised Vitamin B6 health claim or the documented traditional use of a botanical.
KSM-66® Ashwagandha at 600mg, Rhodiola Rosea and Chamomile are traditionally used as adaptogens, a class of botanicals used to help the body adapt to everyday stress. Vitamin B6 contributes to normal psychological function and the normal functioning of the nervous system.
We do not claim this lowers cortisol. There is no authorised health claim for that in the UK, and any brand telling you otherwise is over-claiming.
Broccoli Sprout Extract provides sulforaphane, the bioactive most studied for supporting Phase II liver detoxification, the pathway by which the body processes and clears used hormones. Rosemary is included as a traditional culinary and medicinal herb alongside it.
Chaste Tree (Vitex) is the most-researched Western herb for cycle support and is traditionally used to support a regular monthly cycle. Wild Yam, Fennel and Maca round out the women's herbal heritage of the blend.
Vitamin B6 contributes to normal energy-yielding metabolism, the reduction of tiredness and fatigue, and normal psychological function. Maca, Rhodiola and Ashwagandha are traditionally used to support vitality and stamina.
Vitamin B6 Authorised health claim on the GB Nutrition & Health Claims Register. Botanical Traditional use. Not an authorised health claim.
Gymnema Sylvestre and Chamomile also feature in the blend, traditionally used to support healthy sugar handling and restful sleep respectively.
There is no single answer here, and anyone telling you otherwise is selling something. Here is an honest look at the four options, including the ones that are not us.
| Flissie Cortisol & Stress Support | HRT | Single-ingredient supplements | Other multi-botanical blends | |
|---|---|---|---|---|
| What it is | 11 botanicals plus Vitamin B6. Three capsules a day. | Prescription medicine. Patch, gel, tablet or implant. | One active per bottle. Ashwagandha on its own, or Vitex on its own. | Anywhere from 5 to 25 ingredients. Formulas vary a lot. |
| How it is regulated | Food supplement | Prescription medicine, licensed by the MHRA | Food supplement | Food supplement |
| Who it is for | Daily support through everyday stress, energy dips and cycle changes | Diagnosed menopausal symptoms that need clinical treatment | One thing at a time. Stress, or sleep, or cycle. | Varies. Often built around menopause or PMS specifically. |
| Authorised health claims | Vitamin B6, five authorised claims on the GB register | Medicinal claims under an MHRA licence | Usually one, if any | Depends on the formula |
| What is in it | 10 botanicals described by traditional use, including KSM-66 Ashwagandha at 600mg | No botanicals. Bioidentical or synthetic hormones. | One botanical | Varies. Often soya isoflavones, red clover or dong quai. |
| Alongside HRT | Generally yes. Ask your GP first. | Not applicable | Usually, depending on the ingredient | Check with your GP if it contains phytoestrogens |
| Free from phytoestrogens | No soya isoflavones, no red clover | Not applicable | Depends on the ingredient | Often built on them |
| Cost a month | £29, and the first month is free | NHS prescription charge, or private prescription cost | £8 to £25 per ingredient | £35 to £80 |
Yes Depends No
Cortisol & Stress Support is a food supplement. It is not a replacement for HRT, medical advice or prescribed medication. If your symptoms are affecting daily life, speak to your GP. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
Most cortisol supplements sold online make claims that are not permitted in the UK. You will see these, usually on listings written for the US market where the rules are different.
We are not going to say any of that, so here is exactly where the line sits.
Vitamin B6 has five authorised health claims on the GB Nutrition and Health Claims Register, including contributions to normal psychological function and the reduction of tiredness and fatigue. Those are approved after evidence review and we cite them precisely.
Our ten botanicals are described by their traditional use, which is the correct framing for botanicals sitting on the EFSA Article 13.1 on-hold list. KSM-66® Ashwagandha is traditionally used as an Ayurvedic adaptogen to support the body's response to everyday stress. That is a real thing to say and it is where the evidence sits.
That this lowers your cortisol.
That it reduces belly fat.
That it treats anxiety, burnout or perimenopause.
None of those are authorised, and the ASA banned five supplement ads in the adjacent menopause category in March 2026 for exactly this kind of claim.
If you want a product that promises to lower your cortisol, we are not it.
If you want a well-dosed daily formula built around a clinically researched ashwagandha extract, with every claim traceable to either an authorised register entry or documented traditional use, that is what this is.
Everything you might want to know before you start: cortisol, usage, safety, ingredients and ordering. Can't find your question? Email us and we'll come back within one working day.
Usually a blend of adaptogenic botanicals such as ashwagandha and rhodiola, often with magnesium or B vitamins, taken daily alongside sleep and lifestyle changes. Cortisol is the body's main stress hormone. Adaptogens are traditionally used to help the body adapt to everyday stress, which is why they dominate this category.
Depends what you expect. The evidence for adaptogens is growing but not settled, which is why most botanical claims in the UK sit on the EFSA "on-hold" list rather than being authorised. What we can tell you is that we use KSM-66 Ashwagandha at 600mg, the dose most commonly used in clinical research, rather than an unstated amount of generic root powder. Beyond that, be sceptical of anyone promising a specific outcome.
We are not permitted to claim that, and we would not. There is no authorised health claim in the UK for reducing or lowering cortisol. What we can say is that KSM-66 Ashwagandha, Rhodiola and Chamomile are traditionally used as adaptogens to support the body's response to everyday stress, and that Vitamin B6 contributes to normal psychological function.
Almost certainly not. Home cortisol tests are widely sold but a single reading tells you little, because cortisol naturally swings through the day. If you suspect a medical cause, your GP can arrange a proper 9am serum test, which is the meaningful one. For everyday stress, a test is not a prerequisite for a food supplement.
Take 3 capsules daily with food. Many people split the dose, taking more in the evening if they find ashwagandha relaxing and more in the morning if rhodiola feels energising. There is no single right answer and it is worth experimenting over the first fortnight.
Those are marketing names rather than product categories. "Blocker" in particular implies an effect that is not supported. Ours is a food supplement built around a clinically researched ashwagandha extract, ten other botanicals described by traditional use, and one vitamin with authorised health claims.
Take 3 capsules daily with food. Most customers split the dose, one or two with breakfast and one with dinner, to spread the adaptogenic ingredients across the day. If you find Ashwagandha relaxing, take more of the dose in the evening; if you find Rhodiola energising, take it in the morning.
Most clinical research on the key ingredients (KSM-66 Ashwagandha, Chaste Tree, Maca) measures outcomes over 8 to 12 weeks. Some women notice changes in sleep and stress within the first 2 to 3 weeks; cycle-related changes usually take 2 to 3 full menstrual cycles. Our refund window is designed around that realistic timeline.
Cortisol & Stress Support is formulated for daily, long-term use as part of a balanced diet and lifestyle. The Vitamin B6 dose (2.07 mg) is well below the UK Vitamins & Minerals Guidance level of 10 mg/day, and the botanical doses are within traditional usage ranges. If you're planning to take it for more than 6 months, it's good practice to mention to your GP at your annual check-up.
There is no known interaction and many people take both. Our formula does not contain magnesium, so if you already take it there is no duplication. As with any combination, mention it to your GP or pharmacist if you take prescription medication.
Speak to your GP before starting. Ashwagandha may have additive effects with medications affecting mood or sedation, and the evidence on interactions is limited. This applies to SSRIs including sertraline, and to sedatives and anxiolytics. We would rather you asked than guessed.
Some people find it relaxing rather than sedating, and it is often taken in the evening for that reason. Others notice nothing. Our formula pairs it with Rhodiola, which tends in the other direction, which is why we suggest splitting the dose and seeing which balance suits you.
We do not recommend Cortisol & Stress Support alongside the combined contraceptive pill or the progestogen-only "mini pill", because the Chaste Tree (Vitex agnus-castus) extract may interfere with how hormonal contraceptives work. The Australian Therapeutic Goods Administration has issued a safety alert citing case reports of unintended pregnancy in women using a progestogen-only pill simultaneously with Vitex. Use additional non-hormonal contraception, or pause Cortisol & Stress Support, and speak to your GP if in doubt.
No. Cortisol & Stress Support is not suitable during pregnancy, while trying to conceive, or while breastfeeding. Several of the botanicals (Chaste Tree, Wild Yam, Ashwagandha) are traditionally avoided in these life stages. If you're planning a pregnancy, stop taking Cortisol & Stress Support and speak to your GP or a nutritional therapist for a TTC-specific approach.
Speak to your GP before starting. Ashwagandha has been shown in clinical studies to influence thyroid hormone levels (lowering TSH, raising T3 and T4), which means it may alter how thyroid medication works. The UK Food Standards Agency opened a Call for Evidence on ashwagandha food supplements in 2024, and we're monitoring developments.
No. Wild Yam, Chaste Tree and Maca can have mild hormone-modulating effects through traditional pathways and should be avoided if you have, or have had, a hormone-sensitive condition such as breast, ovarian or uterine cancer, or endometriosis or uterine fibroids, unless your specialist explicitly clears it. Always speak to your oncology or specialist team before starting any new supplement.
Generally yes. None of the 11 ingredients have known direct contraindications with HRT, and many women in our community take both. We always recommend you speak to your prescribing GP before combining any food supplement with prescription medication. Cortisol & Stress Support is a food supplement, not a medicine, and is not an alternative to HRT.
Cortisol & Stress Support is free from gluten, wheat, dairy, lactose, soya, nuts, peanuts, eggs, fish and shellfish. It's manufactured on a site that may handle other allergens, so always check the carton for the most up-to-date allergen statement before use.
Yes. The capsule shell is plant-based hydroxypropylmethylcellulose (HPMC) and all 11 ingredients are plant-derived or synthesised. No animal-derived gelatine, no fish oil, no dairy. Suitable for vegans and vegetarians.
Soya isoflavones and red clover are phytoestrogens, plant compounds that mimic oestrogen in the body. We deliberately built Cortisol & Stress Support without them, so it's a clean fit for women avoiding phytoestrogens for personal preference or medical reasons. Instead, the formula leans on adaptogens (Ashwagandha, Rhodiola), women's-cycle botanicals (Chaste Tree, Wild Yam, Maca, Fennel) and a single targeted vitamin (B6).
Cortisol & Stress Support is manufactured in the UK in a facility certified to Good Manufacturing Practice (GMP) standards. Every batch is tested for ingredient identity, potency and contaminants before release.
Cortisol & Stress Support is designed as a daily nutritional foundation across the full reproductive life stage, from PMS and postpartum through perimenopause and beyond, rather than a product targeting a single life stage. Vitamin B6 is included because it has authorised health claims for hormonal activity, energy, mood and the reduction of tiredness and fatigue, which apply across women's life stages.
No. Cortisol & Stress Support is a food supplement, not a medicine, and is not an alternative to HRT. HRT is a prescription treatment that should be discussed with your GP. This is designed to sit alongside a balanced diet and lifestyle as a daily nutritional foundation. For some women that's instead of HRT, because HRT isn't appropriate or wanted, and for others it's alongside it.
Most established UK women's hormone supplements rely on phytoestrogens (soya isoflavones, red clover, dong quai). Cortisol & Stress Support is built around adaptogens (KSM-66 Ashwagandha, Rhodiola), women's-cycle botanicals (Chaste Tree, Wild Yam, Maca, Fennel) and Vitamin B6. That means it's a better fit if you're avoiding phytoestrogens, and a poorer fit if you specifically want isoflavone-led support.
Cortisol & Stress Support is formulated for women. While Ashwagandha, Rhodiola, Maca and Vitamin B6 have potential relevance for men too, the Chaste Tree (Vitex) component specifically targets the female reproductive cycle and isn't appropriate for daily use by men.
We offer a 60-day money-back guarantee. If you've taken it daily for at least 30 days and you're not seeing the benefits you hoped for, contact us at hello@flissie.com and we'll refund your first bottle. We respond within one working day.
Yes. Your first month is free, then £29 a month for a 30-day supply. Subscriptions are flexible: skip, pause or cancel any time through your account or by email to hello@flissie.com.
No. Gift tubs are a one-off with no auto-renew and nothing to cancel. If you finish it and want to continue, you can start a subscription at any time from this page.
Yes. We renamed it to Cortisol & Stress Support because that describes the formula more accurately: it is built around KSM-66 Ashwagandha at 600mg, with ten more botanicals and Vitamin B6. Tubs printed before the change still carry the old name. Same formula, same doses, same batch testing.
Yes. Cortisol & Stress Support ships free to all UK addresses, no minimum spend. International orders are calculated at checkout based on destination. Import duties or taxes, if applicable in your country, are the recipient's responsibility.
From the team behind FSC-certified bamboo Flissie boxers, the women's comfort brand applying the same standards to daily health.
Hormonal Balance was formulated in the UK by the team behind Flissie's FSC-certified bamboo boxer shorts, the same brand built around women's daily comfort, now applied to daily health. Every ingredient and dose was chosen to anchor the blend around Vitamin B6's authorised health claims for hormonal activity, energy and mood, layered with ten traditionally-used botanicals at clinically researched doses.
Hormonal Balance is manufactured to Good Manufacturing Practice (GMP) and ISO 9001 standards, the same quality frameworks that govern licensed medicines and pharmaceutical-grade production. These cover ingredient sourcing, blending consistency, contamination control, batch traceability and quality assurance at every stage. Capsules are stored in cool, dark, dry conditions to preserve potency from manufacture through to your front door.
Each botanical in Hormonal Balance is supplied as a standardised extract, meaning the active compounds are concentrated to a guaranteed level in every batch, not the variable potency you'd get from raw powdered herbs. Our Ashwagandha is KSM-66, the most clinically researched, full-spectrum root extract on the market. Our Fennel, Maca, Chamomile, Rhodiola, Chaste Tree, Wild Yam, Broccoli Sprout and Rosemary are all supplied as 8:1 to 20:1 standardised extracts, so every capsule delivers consistent potency from the first bottle to the last.
Free from fillers, contaminants and artificial additives. Every batch is independently tested for ingredient identity, heavy metals (lead, arsenic, cadmium, mercury), pesticide residues, and microbiological contaminants, meeting or exceeding international quality standards. Test certificates are kept on file and available on request.
The capsule shell is plant-based hydroxypropylmethylcellulose (HPMC) rather than animal-derived gelatine. All 11 active ingredients are plant-derived or plant-sourced, with no fish oil, no dairy, no eggs and no honey. Hormonal Balance is free from gluten, wheat, dairy, lactose, soya, nuts, peanuts and shellfish - suitable for vegans, vegetarians and most common dietary sensitivities.
Flissie is the women's brand built on comfort that genuinely works, anti-chafing bamboo boxers, sized UK 8 to 30, in FSC-certified bamboo, OEKO-TEX Standard 100 fabric, manufactured to ISO 14001 environmental standards. Hormonal Balance is our first step into women's daily health, and we've held it to the same standard: thoughtfully formulated, transparently labelled, made for women who want products that work without the hype.
